New Data Presented in Late-Breaker Poster
Trius also is presenting early-stage tedizolid data (A-1295a) in the late-breaking poster session. Two randomized, double-blind, placebo-controlled, Phase 1 crossover studies (Study TR701-114 and Study TR701-105) as well as an animal study (5-HTP Mouse Head Twitch Study) demonstrated that tedizolid does not appear to interact with monoamine oxidase (MAO) type A (MAO-A). Published studies have shown that MAO inhibition may be associated with food and drug interactions that affect blood pressure and the body's ability to regulate activity for common neurotransmitters, such as serotonin, norepinephrine and dopamine. In some cases, these interactions can be severe and life-threatening, as for serotonin syndrome.
Antibiotic agents with MAO inhibiting activity such as Zyvox are contraindicated in the presence of antidepressants, Parkinson and vasopressive medicines. Tedizolid studies presented at ICAAC have shown that tedizolid treatment does not produce the hallmark signs of interaction with monoamine oxidase, and is therefore not expected to interact with these medications.
About Trius Therapeutics
Trius Therapeutics, Inc. is a biopharmaceutical company focused on the discovery, development and commercialization of innovative antibiotics for life-threatening infections. The Company's lead investigational drug, tedizolid phosphate, is a once daily, IV and orally administered oxazolidinone in Phase 3 clinical development for the treatment of acute bacterial skin and skin structure infections (ABSSSI). Trius has partnered with Bayer HealthCare for the development and commercialization of tedizolid in Asia and Emerging Markets. In addition to the company's tedizolid clinical program, Trius has initiated IND-enabling studies for its Gyrase-B/ParE development candidate. This dual-inhibitor agent has potent activity against gram-negative bacterial pathogens, including multi-drug resistant strains of
. The Gyrase-B program is one of the two preclinical programs supported by federal contracts. For more information, visit
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