This study found that patients and primary caregivers of patients with PBA symptoms suffer significantly increased burden of illness compared with patients and caregivers of patients with the same underlying neurological conditions but without PBA symptoms. PBA group patients showed significantly greater impairment on measures of general health status, occupational and social function, and a significantly higher incidence of depressive symptoms than controls, both across and within primary neurological disease groups. Inappropriate laughing/crying episodes were associated with feelings of embarrassment, frustration, and the potential for withdrawal and isolation.
About Pseudobulbar Affect People with pseudobulbar affect (PBA) have sudden outbursts of involuntary crying or laughing, even though there may not be anything particularly sad or funny to trigger those emotions. Many people who suffer from PBA describe their episodes as uncontrollable, exaggerated, or different from their true feelings. PBA may occur when certain neurologic diseases or injury damage the areas of the brain that control normal expression of emotion. This damage can disrupt brain signaling, causing a "short circuit" and triggering episodes of involuntary crying or laughing. PBA can occur in people diagnosed with a variety of otherwise unrelated neurologic conditions such as
Lou Gehrig's disease (ALS), multiple sclerosis (MS), Parkinson's disease, stroke, traumatic brain injury (TBI), and Alzheimer's disease. For more information about PBA, please visit
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About Avanir Pharmaceuticals, Inc.Avanir Pharmaceuticals, Inc. is a biopharmaceutical company focused on bringing innovative medicines to patients with central nervous system disorders of high unmet medical need. As part of our commitment, we have extensively invested in our pipeline and are dedicated to advancing medicines that can substantially improve the lives of patients and their loved ones. For more information about Avanir, please visit