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Avanir Pharmaceuticals Announces Publication Of PBA Burden Of Illness Study

ALISO VIEJO, Calif., Sept. 5, 2012 /PRNewswire/ --  Avanir Pharmaceuticals, Inc. (NASDAQ: AVNR) announced today that Advances in Therapy published results from a U.S. survey conducted by Harris Interactive, comparing Quality of Life (QOL), Quality of Relationships (QOR), health status and daily function of neurologic patients with and without symptoms of pseudobulbar affect (PBA). A link to the online article can be accessed at

"The results from this survey demonstrate that PBA symptoms are associated with considerable burden incremental to that of the underlying neurological conditions, affecting quality of life and relationships, health status, and social and occupational functioning," said Randall Kaye, MD, chief medical officer at Avanir Pharmaceuticals. "This important information will help healthcare practitioners better appreciate and understand the multi-faceted impact of PBA symptoms on patients and their caregivers."

About the StudyAn online survey was administered to neurologic patients across six underlying conditions commonly associated with PBA: Alzheimer's disease and other dementias, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, stroke, and traumatic brain injury. The 1,052 respondents included 399 PBA group participants who scored 13 or greater on the Center for Neurologic Study Lability Scale and 653 matched neurologic controls. In order to measure various aspects of burden of illness in PBA group respondents and controls, a series of medically validated scales were administered, including:
  • The 36-Item Short Form Health Survey (SF-36)
  • QOL and QOR visual analog scales measuring impact of involuntary laughing or crying episodes
  • The Work Productivity and Activity Impairment (WPAI) Questionnaire: General Health V2.0
  • The Center for Epidemiologic Studies Depression Scale 10-item short form (CES-D10)
  • The Screen for Caregiver Burden (SCB)

The PBA group reported significantly worse scores versus non-PBA controls on the SF-36 health survey (P < 0.05 for all physical and mental component and summary scores), QOL and QOR visual analog scales (P < 0.05 for both), and workplace productivity items (P ≤ 0.05). Most patients in the PBA group and over half in the control group had significant depressive symptoms as determined by a CES-D10 scale score of 10 or greater (87% PBA group vs. 56% controls; P < 0.05). PBA symptoms contributed a great deal or were the main cause of becoming housebound for 24% and placement in supervised living for 9% of PBA group respondents. In addition, caregiver burden prevalence and distress scores were higher among caregivers in the PBA group (13.7 and 41.5, respectively; P = 0.05) compared with the control group (10.2 and 37.6, respectively; P = 0.05).

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