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First Patient Procedure Using The ClearPoint® Neuro Intervention System Performed At Memorial Sloan Kettering Cancer Center In Pediatric Brain Cancer Clinical Trial

MEMPHIS, Tenn. and MUNICH, Aug. 14, 2012 /PRNewswire/ -- MRI Interventions, Inc. (OTCBB: MRIC) and Brainlab AG announced today that the ClearPoint ® Neuro Intervention System is being used in a groundbreaking clinical trial for the treatment of pediatric brain cancer.  Dr. Mark Souweidane (Professor and Vice Chairman, Department of Neurological Surgery; Director of Pediatric Neurosurgery at New York Presbyterian Hospital/Weill Cornell and Memorial Sloan Kettering Cancer Center) and a team at Memorial Sloan Kettering Cancer Center used the ClearPoint System in the delivery of a cancer-fighting agent into the tumor of a pediatric patient while viewing three-dimensional MRI images of the delivery in real-time throughout the procedure. This was the first case in a new clinical trial to administer and study the effects of the radio immunotherapy drug, 124I-8H9, on a diffuse infiltrative pontine glioma (DIPG) tumor, a rare and incurable form of pediatric brain cancer.

Brain tumors of this type are located in the brain stem, which prohibits surgical removal. Radiation is the standard treatment for DIPG, but it does not provide a cure; most patients die within months of diagnosis.  Previous attempts to administer a drug therapy to significantly improve the survival of children afflicted with DIPG have failed.

Dr. Souweidane's group, in collaboration with other investigators, is using the ClearPoint System in the administration of precise amounts of the agent directly into the tumor via MRI-guided convection-enhanced delivery.  The ability to view drug delivery in real-time is crucial in these cases so that the surgeon can confirm that the potent agent has reached the tumor in the correct amount, as well as to avoid hitting healthy critical structures around the tumor. The ClearPoint System allows the surgeon to advance a drug delivery canula in a precise trajectory through the brain and into the tumor, then observe the infusion of the drug in real-time as it slowly "fills" the tumor.

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