Today's Volume: 11.5 millionAverage Volume: 5.5 million Volume % Change: 286% From a technical perspective, ESRX is gapping up sharply higher here with monster volume, and it's started to enter breakout territory since the stock has taken out some overhead resistance levels at $59.50 to $58.98. >>5 Pharma Stocks Everyone Hates Traders should now look for long-biased trades once ESRX triggers its next major breakout trade. That trade will hit once ESRX takes out its 2011 high of $60.89 with high volume. At last check, ESRX has hit an intraday high of $60.85 and volume is well above its three-month average action of 5,484,210 shares. Traders should look for a sustained move or close above 60.89 with volume that's near or above 5,484,210 shares. If we get that action soon, then look for ESRX to hit $65 to $70 in the near future. As of the most recently reported period, Express Scripts was one of Lee Ainslie's Maverick Capital holdings and also showed up in Third Point's portfolio.