July 31, 2012
/PRNewswire/ -- Synergy Pharmaceuticals Inc. (Nasdaq: SGYP), a developer of new drugs to treat gastrointestinal disorders and diseases, announced today that poster presentations on plecanatide that will be given at three separate Gastroenterology society meetings this fall.
Plecanatide is currently being developed for the treatment of patients suffering with chronic constipation (CIC) and irritable bowel syndrome-constipation predominant (IBS-C). Plecanatide is an agonist of the guanylate cyclase-C receptor and is the superior analog of the natriuretic peptide, uroguanylin, the physiologic ligand of GC-C.
The scheduled locations, dates, titles and timing of the presentations are:
JOINT INTERNATIONAL NEUROGASTROENTEROLOGY AND MOTILITY MEETING to be held
September 6-8, 2012
Plecanatide, a Superior Analog of Uroguanylin, as an Oral Drug Candidate for Treatment of Gastrointestinal Functional Disorders and Diseases.
and Kunwar Shailubhai. [Poster presentation
8 September 2012
UNITED EUROPEAN GASTROENTEROLOGY WEEK to be held
October 20-24, 2012
Amsterdam, The Netherlands
Orally Administered Plecanatide, A Guanylate Cyclase-C Agonist, Acts in the Proximal Intestine to Stimulate Fluid Secretion to Normalize Bowel Movement.
(P1003) Authored by
and Kunwar Shailubhai. [Poster presentation date to be announced]
AMERICAN COLLEGE OF GASTROENTEROLOGY ANNUAL MEETING to be held
October 19-24, 2012
Las Vegas, NV
Orally Administered Plecanatide, A Guanylate Cyclase-C Agonist, Acts in the Lumen of the Proximal Intestine to Facilitate Normal Bowel Movement in Mice and Monkeys.
(P451) Authored by
, Kunwar Shailubhai. [Poster presentation
21 October 2012
About Synergy Pharmaceuticals Inc.
Synergy is a biopharmaceutical company focused on the development of new drugs to treat gastrointestinal disorders and diseases. Synergy's lead proprietary drug candidate plecanatide is a synthetic analog of the human gastrointestinal (GI) hormone uroguanylin, and functions by activating the guanylate cyclase C receptor on epithelial cells of the GI tract. Synergy completed a Phase I study of plecanatide in healthy volunteers and a Phase IIa clinical trial in chronic idiopathic constipation (CIC) patients. In October, 2011, Synergy initiated dosing of patients in a major Phase II/III clinical trial of plecanatide to treat CIC. Plecanatide is also being developed to treat constipation-predominant irritable bowel syndrome (IBS-C), with the first trial in IBS-C patients planned for the second half of 2012. Synergy's second GC-C agonist SP-333 is currently in pre-clinical development to treat inflammatory bowel diseases. More information is available at
Plecanatide is a member of a new class of essentially non-systemic drugs, referred to as guanylate cyclase C (GC-C) agonists, that are currently in development to treat CIC and IBS-C. Plecanatide is a synthetic analog of uroguanylin, a natriuretic hormone that regulates ion and fluid transport in the GI tract. Orally-administered plecanatide binds to and activates GC-C receptors expressed on epithelial cells lining the GI mucosa, resulting in activation of the cystic fibrosis transmembrane conductance regulator (CFTR), and leading to augmented flow of chloride and water into the lumen of the gut. Activation of the GC-C receptor pathway is believed to facilitate bowel movement as well as producing other beneficial physiological responses including improvement in abdominal pain and inflammation. In animal models, oral administration of plecanatide promotes intestinal secretion and also ameliorates GI inflammation.