Bapineuzumab is being co-developed by Johnson & Johnson (JNJ) with certain economic rights held by Irish drug maker Elan (ELN). Investors widely expected bapineuzumab clinical trials to fail based on similarly poor results from mid-stage studies presented in July 2008.
The study announced Monday enrolled patients with mild to moderate Alzheimer's who also carried a gene known as ApoE4 that confers a higher risk of developing the disease. Patients treated with bapineuzumab showed no cognitive or functional improvement compared to patients treated with a placebo, Pfizer said.
Three other phase III studies of bapineuzumab, enrolling both Apoe4 carriers and non carriers, are still underway with results expected later this year.Elan shares are down 16% to $11.26 in Monday after-hours trading. --Written by Adam Feuerstein in Boston.
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