This Day On The Street
Continue to site right-arrow
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
Stocks Under $10 with 50-100% upside potential - 14 days FREE!

Vitamin D Supplementation May Not Reduce Cholesterol-Related Heart Disease Risk, New Study Finds

Stocks in this article: DGX

MADISON, N.J., July 17, 2012 /PRNewswire/ -- Raising vitamin D to optimal from deficient blood levels may not improve total cholesterol and other blood lipids, key markers of cardiovascular disease risk, according to a study published today in Circulation, a publication of the American Heart Association. The study, by researchers at Quest Diagnostics (NYSE: DGX) and The Rockefeller University, is the first large-scale examination of the clinical impact of correcting vitamin D deficiency on lipid levels and associated cardiovascular disease risk.

"Prior studies have associated low vitamin D level with an unhealthy lipid profile, but the effect of therapeutically correcting a vitamin D deficiency by itself on lipids is unclear," said lead investigator Manish Ponda, M.D., M.S., assistant professor of Clinical Investigation for The Rockefeller University's Laboratory of Biochemical Genetics and Metabolism. "This novel study on a large U.S. population suggests that correcting a vitamin D deficiency may not translate into a clinical benefit on the lipid profile. Patients should follow their physician's advice on whether vitamin D supplements are right for them."

An accompanying editorial in Circulation characterizes the study as having "great importance" for demonstrating that biomarkers, such as vitamin D, that are associated with disease risks in certain types of studies may not be found to cause those risks in other types of research.

Optimal vitamin D levels associated with favorable lipids

Heart disease is the number one killer of men and women in the United States, and individuals with high total cholesterol levels have twice the risk of heart disease as people with optimal levels. Several studies show an unfavorable association between deficient levels of vitamin D and cardiovascular disease markers such as total cholesterol and other lipids. However, randomized controlled studies are pending to assess if vitamin D deficiency is a cause or merely a marker of poor heart health and the effect of therapy to correct a deficiency.

The researchers conducted two studies on patients tested for vitamin D and lipids by Quest Diagnostics in the United States. The first study involved a cross-sectional analysis of 107,811 patients to assess differences in lipid levels between those with optimal and deficient vitamin D levels. Cross-sectional studies evaluate a study population in one moment in time.

The analysis found that patients with optimal levels of vitamin D, defined as 30 ng/ml or higher, had a statistically significant lower lipid risk profile, including lower overall total cholesterol, LDL ("bad") cholesterol and triglycerides, and higher HDL ("good") cholesterol, compared to those with deficient levels measuring less than 20 ng/ml.

1 of 3

Select the service that is right for you!

Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!


DOW 17,804.80 +26.65 0.15%
S&P 500 2,070.65 +9.42 0.46%
NASDAQ 4,765.38 +16.9840 0.36%

Brokerage Partners

Rates from

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs