This Day On The Street
Continue to site
ADVERTISEMENT
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here

Compugen Announces Validation Results For A Second Potential Immune Checkpoint Target For Cancer Immunotherapy

Compugen Ltd. (NASDAQ: CGEN) announced today results demonstrating the therapeutic potential of CGEN-15022, a Compugen-discovered B7/CD28-like membrane protein, as an immune checkpoint target for treatment of multiple cancers. The results indicate that CGEN-15022 is expressed in numerous types of epithelial cancers with significant unmet clinical needs, such as liver, colorectal, lung and ovarian cancers. These findings, together with previously disclosed results pointing to its negative costimulatory activity, strongly support CGEN-15022’s potential as a compelling drug target for treatment of these cancers through monoclonal antibody (mAb) therapy, an area of great interest to the pharmaceutical industry.

The Company previously announced that CGEN-15001T, the first protein to undergo validation, of nine novel molecules predicted in silico by Compugen to be B7/CD28-like proteins, demonstrated expression in solid cancers and hematological malignancies, such as prostate cancer, melanoma, Hodgkin's lymphoma and Non-Hodgkin's lymphoma, such as T and B cell lymphomas. The different expression profiles of CGEN-15022 and CGEN-15001T not only provide important differentiating characteristics between the two novel targets, but also offer promising opportunities for utilizing these proteins as mAb targets in order to treat a broad set of key cancer indications with significant unmet medical needs.

Negative costimulatory proteins play critical roles as immune checkpoints, turning down or silencing the active immune system to prevent autoimmunity and to protect tissues from damage during inflammation. Tumor cells "highjack" this process and express these immune checkpoints in order to protect the tumor from destruction by the immune system. Therefore utilizing an antibody to block this function is predicted to remove the immune silencing effect and enable the immune system to attack and destroy the tumor, thus serving as a very promising approach for cancer immunotherapy.

Furthermore, since the extracellular domain of the protein is responsible for the immune silencing effect, a soluble Fc fused protein presenting the extracellular domain of the protein should have therapeutic potential for immune related diseases, such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease and psoriasis. To date, Compugen has announced that five out of the first six B7/CD28-like proteins to undergo experimental testing, have demonstrated positive results in well-established disease animal models for various immune related diseases.

1 of 4

Check Out Our Best Services for Investors

Action Alerts PLUS

Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
14-Days Free
Only $9.95
14-Days Free
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!
SYM TRADE IT LAST %CHG

Markets

DOW 18,077.27 -2.87 -0.02%
S&P 500 2,114.42 -3.27 -0.15%
NASDAQ 5,070.4750 -21.61 -0.42%

Partners Compare Online Brokers

Free Reports

Top Rated Stocks Top Rated Funds Top Rated ETFs