GTx, Inc. (Nasdaq: GTXI) announced today there will be two scientific presentations on the effects of enobosarm, a selective androgen receptor modulator (SARM), on improving physical function in cancer patients on June 30, 2012, between 2:30 and 4:00pm eastern daylight time, at the MASCC/ISOO 2012 International Symposium held at the Hilton New York Hotel in New York, New York.
James T. Dalton, PhD., VP, Chief Scientific Officer of GTx, will present data from the company’s Phase IIb clinical study of enobosarm providing evidence that enobosarm may play an important role in the management of cancer patients with muscle wasting by improving physical function. Of the 159 subjects randomized into the study, 103 had physical function (stair climb) assessed at both baseline and following 16 weeks of treatment. 24% of these subjects had lost less than 5% of weight. Distribution of weight loss was similar across genders; however, subjects with less than 5% weight loss were more likely to have a normal performance status (ECOG=0), while subjects with 5% or more weight loss at baseline demonstrated a comparatively worse performance status. Significant improvement in physical function was observed in enobosarm treated subjects, regardless of baseline weight loss, while placebo subjects failed to improve.
Mitchell S. Steiner, MD, CEO of GTx, will present data indicating that enobosarm may positively impact the management of cancer-related muscle wasting. In GTx’s Phase IIb enobosarm clinical study, lower baseline testosterone levels correlated with greater baseline weight loss;.hypogonadal male subjects had greater weight loss than eugonadal males. Baseline physical function (stair climb power) of subjects in the study was higher among eugonadal versus hypogonadal males. After 16 weeks of treatment, enobosarm significantly improved physical function in both hypogonadal and eugonadal subjects compared to placebo.
Enobosarm is a SARM which binds to the androgen receptor and is designed to deliver the beneficial effects of androgens while minimizing unwanted clinical side effects. GTx conducted its Phase IIb clinical study of enobosarm in 159 cancer patients (average age of 66 years) in 35 sites in the United States and Argentina. Participants were randomized to receive placebo, 1 mg or 3 mg oral tablet of enobosarm once daily for 16 weeks. Average reported weight loss prior to entry among all subjects was 8.8%, and subjects were allowed to have standard chemotherapy during the trial. The drop-out rate during the trial was 33%. The study met its primary endpoint of absolute change in total lean body mass (muscle) compared to placebo after 16 weeks of treatment.
Select the service that is right for you!COMPARE ALL SERVICES
Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.
- $2.5+ million portfolio
- Large-cap and dividend focus
- Intraday trade alerts from Cramer
- Weekly roundups
Access the tool that DOMINATES the Russell 2000 and the S&P 500.
- Buy, hold, or sell recommendations for over 4,300 stocks
- Unlimited research reports on your favorite stocks
- A custom stock screener
- Upgrade/downgrade alerts
Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.
- Diversified model portfolio of dividend stocks
- Alerts when market news affect the portfolio
- Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.
- Real Money + Doug Kass Plus 15 more Wall Street Pros
- Intraday commentary & news
- Ultra-actionable trading ideas
Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.
- 100+ monthly options trading ideas
- Actionable options commentary & news
- Real-time trading community
- Options TV