(NASDAQ: PCRX) today announced new data that demonstrate opioid-related adverse drug events (ORADEs) following laparoscopic or open gastrointestinal (GI) surgeries increased total hospitalization costs by up to $12,724 and as much as doubled the length of hospital stay (LOS), depending on the type of surgical procedure performed. These findings were presented today during a poster session at the American Society of Colon and Rectal Surgeons (ASCRS) annual meeting in San Antonio, Texas.
Data from this regional retrospective analysis were drawn from 26 participating member hospitals of VHA Southeast (a regional office of VHA, Inc.), and included patients who underwent select laparoscopic or open GI surgeries and received opioid-based pain management regimens from January 2009 to December 2010. The research was supported by Pacira Pharmaceuticals, Inc.
Compared to patients who did not experience an ORADE:
- Mean total hospitalization costs increased by $7,949 and $12,724 for patients experiencing an ORADE after a laparoscopic or open GI procedure, respectively.
- Mean LOS was 1.5-1.9 times and 1.3-2.0 times longer for patients experiencing an ORADE after a laparoscopic or open GI procedure, respectively.
“These types of analyses continue to quantify the significant impact opioids have on our patients and the economics of hospital care in the United States,” said Dave Stack, president and CEO of Pacira Pharmaceuticals. “These data demonstrate that even in laparoscopic procedures, which are less invasive and intended to provide quicker patient recovery, opioid-related adverse events including nausea, vomiting, constipation, urinary retention and respiratory depression can significantly impact patient healing and hospital discharge.”
Additionally, new national data on the impact of ileus following postsurgical opioid use were presented during a poster session held today at the 17th Annual Meeting of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) in Washington, D.C. Ileus is a partial or complete blockage of the small and/or large intestine resulting in greatly impaired or lost bowel function. It is a complication significantly associated with abdominal procedures that can be exacerbated by opioid use.