This Day On The Street
Continue to site
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here

J&J Scores Big With Prostate Cancer Pill

CHICAGO ( TheStreet) -- Johnson & Johnson's (JNJ - Get Report) Zytiga improved survival in "pre-chemo" prostate cancer patients by 33% and more than doubled the time before cancer worsened compared to control, according to results from a phase III study to be presented today at the American Society of Clinical Oncology (ASCO) annual meeting.

Zytiga, a pill, was first approved in 2011 as a treatment for prostate cancer patients who have previously been treated with chemotherapy. The new data released for the first time Saturday open a much larger commercial opportunity for J&J because if approved, Zytiga will become a treatment option for men with less advanced prostate cancer.

J&J reported Zytiga sales of $200 million, half of those in the U.S., in the first quarter.

The strong Zytiga results are expected to have positive spillover effects for Medivation (MDVN - Get Report), which is developing its own prostate cancer pill MDV3100 that is similar -- and perhaps superior to -- Zytiga.

Both Zytiga and MDV3100 work similarly by interfering with the way prostate cancer cells feed from testosterone produced in the body.

Dendreon (DNDN), however, may emerge from this year's ASCO meeting with a limp. Based on today's Zytiga results, the pill could steal prostate cancer patients away from its Provenge immunotherapy.

In the J&J study, 1,088 patients with prostate cancer who had not yet received chemotherapy were treated with Zytiga plus the steroid prednisone or a placebo plus prednisone.

The study was stopped early after an interim analysis found that treatment with Zytiga reduced the risk of prostate cancer worsening or death (also known as progression-free survival) by 57% compared to placebo. The result was highly statistically significant, with a p value of 0.0001, meaning there was less than a one-hundredth of 1% chance that the outcome was derived by chance.

Prostate cancer patients treated with placebo reported a median progression-free survival (PFS) of 8.3 months, while the median PFS for Zytiga-treated patients has not yet been reached. "[Progression] events are coming in slowly, which demonstrates the benefit that Zytiga is having for patients," said Dr. Michael Meyers, a Johnson & Johnson vice president in charge of Zytiga's clinical development.
1 of 2

Check Out Our Best Services for Investors

Action Alerts PLUS

Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
14-Days Free
Only $9.95
14-Days Free
Dividend Stock Advisor

David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks

Every recommendation goes through 3 layers of intense scrutiny—quantitative, fundamental and technical analysis—to maximize profit potential and minimize risk.

Product Features:
  • Model Portfolio
  • Intra Day Trade alerts
  • Access to Quant Ratings
Real Money

More than 30 investing pros with skin in the game give you actionable insight and investment ideas.

Product Features:
  • Access to Jim Cramer's daily blog
  • Intraday commentary and news
  • Real-time trading forums
Only $49.95
14-Days Free
14-Days Free
DNDN $0.06 -6.02%
JNJ $112.49 0.24%
MDVN $59.65 1.00%
AAPL $92.82 -0.85%
FB $117.53 -0.45%


Chart of I:DJI
DOW 17,644.21 -7.05 -0.04%
S&P 500 2,053.26 +2.14 0.10%
NASDAQ 4,729.1960 +3.5570 0.08%

Free Reports

Top Rated Stocks Top Rated Funds Top Rated ETFs