- Enhanced cytotoxicity induced by the oncology agents bortezomib or 17AAG, even in the presence of bone marrow stromal cells or exogenous IL-6;
- Contributed to cell death in combination with these agents and as a single agent with fresh bone marrow aspirates from myeloma patients;
- Inhibited growth of multiple myeloma cells in vivo alone and in combination with these agents
Pre-Clinical Data Demonstrates Promising Potential Of MannKind’s IRE1α Inhibitor To Treat Multiple Myeloma
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