Rexahn Pharmaceuticals, Inc. (NYSE Amex: RNN), a clinical stage pharmaceutical company developing and commercializing potential best in class oncology and CNS therapeutics, today announced the publication of a research article in
Journal of Medicinal Chemistry
[55: 4521-4525, 2012] on the anti-tumor activity of its RX-3117 compound.
The data demonstrates the synthesis of RX-3117 and its 2’-deoxy analogue, as well as its in vitro cell-line activity and strong in vivo anti-tumor effect.
“This study provides further evidence of RX-3117’s potential as an anti-cancer compound,” said Rick Soni, President of Rexahn. “In the preclinical study, RX-3117 significantly inhibited growth of human cancer cells in vitro and the growth of tumors in in vivo models of nude mice.”
RX-3117 is a small molecule, new chemical entity (NCE) and nucleoside compound. Potential indications of RX-3117 are solid tumors including colon, lung and pancreatic cancers. In preclinical trials, RX-3117 has demonstrated its ability to overcome cancer drug resistance in cancer cells, in particular, gemcitabine-resistance in the human lung cancer cell. Rexahn has been awarded patents for RX-3117 in the US, China, Europe, Korea and Mexico.
About Rexahn Pharmaceuticals, Inc.
Rexahn Pharmaceuticals is a clinical stage pharmaceutical company dedicated to developing and commercializing first in class and market leading therapeutics for cancer, CNS disorders, sexual dysfunction and other unmet medical needs. Rexahn currently has three drug candidates in Phase II clinical trials, Archexin®, Serdaxin®, and Zoraxel™ and a robust pipeline of preclinical compounds to treat multiple cancers and CNS disorders. Rexahn also operates key R&D programs of nano-medicines, 3D-GOLD, and TIMES drug discovery platforms. For more information, please visit
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