3. 2012 Lexus RX 450h Hybrid
Combined miles per gallon: 29.7
This is about the best mileage you're going to get out of a vehicle with 80 cubic feet of cargo room, but it doesn't come cheap. It's close to 10 miles per gallon more efficient than its standard RX 350, but also costs about $6,000 more. Fortunately, it still has all the 350's luxury features and options, including power rear door, parking sensors, rear camera, heated seats and heads-up gauge displays on the windshield.