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CVS Caremark And Brigham And Women's Hospital Research Finds Sharp Drop In Adherence To Cardiovascular Medications For Patients In Medicare Part D "Donut Hole"

WOONSOCKET, R.I., April 17, 2012 /PRNewswire/ -- Research published today in the journal Circulation: Cardiovascular Quality and Outcomes found that Medicare Part D beneficiaries with cardiovascular conditions who had no financial assistance during the "donut hole" coverage gap were 57% more likely to discontinue their cardiovascular medications than those beneficiaries who had consistent drug coverage. While the study found no increase in short-term negative health issues during the coverage gap, the long-term health impact of non-adherence to cardiovascular drugs during the coverage gap is unclear.


The study, entitled "Beneficiaries with Cardiovascular Disease and the Part D Coverage Gap," was conducted by researchers from Harvard University, Brigham and Women's Hospital and CVS Caremark and examined prescription drug usage for cardiovascular conditions (i.e., hypertension, high cholesterol, atrial fibrillation, congestive heart failure or cardiovascular disease) among more than 122,000 Medicare beneficiaries who reached the Medicare Part D donut hole in 2006 or 2007.

The researchers concluded that cost-sharing mechanisms like the coverage gap disrupted the beneficial effects of drug coverage expansion under Part D for elderly beneficiaries with cardiovascular conditions, instead prompting them to discontinue their medications more frequently than beneficiaries who had stable drug coverage. In addition, the results showed that beneficiaries were no more likely to switch to generic medications during the donut hole. 

"Consistent with other research on the impact of the Medicare Part D coverage gap on medication adherence, we found that exposure to 100 percent of drug costs in the gap led to abrupt discontinuation of essential cardiovascular medications, even among those with cardiovascular conditions who might experience more immediate consequences as a result of drug discontinuation," said Jennifer M. Polinski, ScD, MPH, of the Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women's Hospital and Harvard Medical School, and lead author of the study. "While the results did not demonstrate any short-term health issues as a result of this dramatic drop-off in medication adherence, it is not clear whether coverage gap-related lapses in financial assistance for drugs affects patient health outcomes for this high risk population over the long term."

"This study is part of our ongoing research collaboration with Harvard and Brigham and Women's Hospital to help better understand those factors that can improve pharmacy care," said Troyen A. Brennan, MD, MPH, executive vice president and chief medical officer of CVS Caremark, who heads the research initiative that conducted the study. "The Affordable Care Act incrementally eliminates the 'donut hole' by 2020, but until that time we want to make sure beneficiaries are making the best decisions to promote good health. For our part, we will continue to advocate for plan strategies that promote the use of low cost medications, because cost remains a big issue in helping patients stay on their medications as directed."

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