PharmAthene's rPA anthrax vaccine program has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Disease, National Institutes of Health and the Biomedical Advanced Research and Development Authority.
SparVax™ is a novel second generation anthrax vaccine being developed to protect against inhalation anthrax, the most lethal form of anthrax infection in humans. The vaccine contains highly purified recombinant protective antigen (rPA) and has been shown to stimulate protection against anthrax by eliciting a specific immune response to one of the primary proteins excreted by the Bacillus anthracis organism. Unlike the first generation anthrax vaccine and other rPA-based anthrax vaccines in development, SparVax™ is produced using E. coli, which enables a much more robust and scalable manufacturing process. In addition, SparVax™ is capable of being produced at greater than 150 million rPA vaccine equivalent doses per year (at 50 mcg per dose) using a single 1,500-liter fermentor. The unique manufacturing process also mitigates the detrimental effect of proteases. SparVax™ is expected to undergo additional Phase II clinical testing in 2012.
About PharmAthene, Inc.
PharmAthene was formed to meet the critical needs of the United States and its allies by developing and commercializing medical countermeasures against biological and chemical weapons. PharmAthene's lead product development programs include:
- SparVax™ - a second generation recombinant protective antigen (rPA) anthrax vaccine
- Valortim® - a fully human monoclonal antibody for the prevention and treatment of anthrax infection
- rBChE - a novel bioscavenger for the prevention and treatment of morbidity and mortality associated with exposure to chemical nerve agents
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