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Synageva BioPharma And Mitsubishi Tanabe Pharma Corporation Expand Development Collaboration With Second Program

Synageva BioPharma Corp. (“Synageva”) (NASDAQ:GEVA), a clinical stage biopharmaceutical company developing therapeutic products for rare disorders, announced today an expansion of its previous collaboration with Mitsubishi Tanabe Pharma Corporation (Head Office; Osaka, Japan, “MTPC”) to develop a second protein therapeutic for an undisclosed orphan disease using Synageva’s product development capabilities and proprietary protein expression platform.

“The expansion of our relationship with Mitsubishi Tanabe is an exciting one for the company. It validates our experience in product development and manufacturing for rare diseases and allows the team to continue its focus on our lead development programs,” said Sanj K. Patel, Synageva’s President and Chief Executive Officer.

"We are pleased to expand our collaborative alliance with Synageva for orphan diseases. The synergy of Synageva’s innovative technologies and MTPC’s expertise in R&D of biologics will seek to create protein therapeutics that contribute to healthy life around the world," said Dr. Masayuki Mitsuka, Board Director, Executive Officer, Global Product Strategy of MTPC.

Terms of the expanded collaboration

Under the terms of the agreement, Mitsubishi Tanabe Pharma will make an upfront payment of $9 million. Synageva will receive reimbursement for development costs, potential future development and commercial milestone payments, as well as royalties from potential product revenue. Today’s announced agreement does not impact Synageva’s previously stated net operating loss guidance of between $40 and $45 million for 2012.

About Synageva BioPharma Corp.

Synageva is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of therapeutic products for patients with life-threatening rare diseases and unmet medical need. Synageva has several protein therapeutics in its pipeline. The company has assembled a team with a proven record of bringing orphan therapies to patients.

Synageva’s lead program, SBC-102 is being developed as an enzyme replacement therapy for Lysosomal Acid Lipase (LAL) Deficiency, a lysosomal storage disorder (LSD), and is a recombinant form of the human LAL enzyme. SBC-102 is currently being evaluated in global clinical trials and has been granted orphan designations by the U.S. Food and Drug Administration (“FDA”) and the European Medicines Agency. Additionally, SBC-102 received fast track designation by the FDA.

Further information regarding Synageva BioPharma Corp. is available at www.synageva.com.

About Mitsubishi Tanabe Pharma Corp.

Mitsubishi Tanabe Pharma Corporation is a research-driven pharmaceutical company based in Osaka. Our philosophy states that “We contribute to the healthier lives of people around the world through the creation of pharmaceuticals”. In accordance with this philosophy, we strive to continually discover drugs with new value and to provide those drugs to patients around the world. Mitsubishi Tanabe Pharma is taking on the challenge of drug discovery in the fields of autoimmune disorders, diabetes, and renal diseases, as well as in other fields with high levels of unmet medical needs. To those ends, the Company is strengthening its R&D pipeline.

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