About CO-1686CO-1686 is a targeted covalent (irreversible) inhibitor of EGFR mutations. CO-1686 was designed to selectively target both the initial activating EGFR mutations as well as the T790M resistance mutation, while sparing wild-type, or “normal” EGFR at anticipated therapeutic doses. CO-1686 is being clinically developed in patients with NSCLC associated with mutations in EGFR and has the potential to cause a lower incidence of skin rash and diarrhea, the primary toxicities associated with other EGFR inhibitors. Preclinical data presented in late 2011 demonstrated that CO-1686 causes tumor shrinkage in T790M-driven NSCLC xenograft models, and resulted in significant tumor growth inhibition at a variety of doses.
Clovis Oncology Announces Enrollment Of First Patient In First Human Study Of Oral EGFR Mutant-Selective Inhibitor CO-1686
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