This Day On The Street
Continue to site
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here

Nuvilex Announces Advance In Gene Therapy For Encapsulated Living Cells Using Magnetic Nanoparticles

Nuvilex, Inc. (OTCQB: NVLX), an emerging international biotechnology provider of cell and gene therapy solutions through its associate SG Austria, announced today a significant advance in gene therapy with a new, unique, and specialized system for induction of gene expression in encapsulated cells.

In a recent publication in the Journal of Controlled Release, SG Austria and its research partners described a new system for induction of gene expression, or the means for stimulating a gene to be expressed within cells, including those that have been encapsulated and implanted in the body.

The process described in the publication involves the stimulation of pre-programmed living cells, encapsulated using the Cell-in-a-Box® technology, to express therapeutic genes under the control of a heat shock protein inducible promoter. This is done by simultaneously co-encapsulating pre-programmed cells and magnetic nanoparticles, which are much smaller than the cells. When subjected to an alternating magnetic field, the magnetic nanoparticles inside the capsules vibrate, producing heat. This results in a localized, temporary increase in temperature inside the capsules. This heat causes specialized heat shock proteins in the cells to induce expression of the therapeutic gene(s).

Although both cell and gene therapies have an enormous range of potential applications, a critical issue in modern molecular biology has been to be able to regulate and control gene expression. Therefore, many systems have been created to regulate gene expression. Those gene expression systems currently available mostly rely on small molecules such as hormones or antibiotics as inducers. Unfortunately, administration of some of these inducers is difficult to control, the effects on gene regulation are typically slow, and they do not easily shut off once turned on. The new system developed by SG Austria and its partners will allow doctors in the future to more accurately control both dosage and the synthesis of specific proteins for treating a disease.

1 of 2

Check Out Our Best Services for Investors

Action Alerts PLUS

Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
14-Days Free
Only $9.95
14-Days Free
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!


DOW 18,037.97 -42.17 -0.23%
S&P 500 2,108.92 -8.77 -0.41%
NASDAQ 5,060.2460 -31.8390 -0.63%

Partners Compare Online Brokers

Free Reports

Top Rated Stocks Top Rated Funds Top Rated ETFs