With regards to adoption of the physician community, we continue to see 70 to a 100 subscribers each week. We’ve seen this over the past year and we think it’s a very positive sign for the product, as more and more physicians get exposure to NUEDEXTA and the benefits that it brings to patients. Then, finally, in the fourth quarter of last year, we deployed our institutional sales force, approximately 32 representatives focused on the long-term care setting and we’ve seen a very strong uptake within that segment, with long-term care now representing over 50% of the total prescriptions written for NUEDEXTA.
Turning now to a quick overview on pseudobulbar affect and the PBA market, for those of you not familiar with PBA, PBA is a neurologic disorder that causes uncontrolled emotional outbursts. In our case, we studied episodes of uncontrolled laughing and/or crying in our Phase III clinical studies. And what’s important about pseudobulbar affect is it must occur secondary to a neurologic disease or injury. So it occurs secondary to multiple sclerosis, to Alzheimer’s disease, and other forms of dementia, secondary to Parkinson’s, dramatic brain injury or stroke.
And what happens is there is essentially a legion in the brain, because of the disconnect between the front and the back of the brain, these people no long are allowed to control their emotions and they have these uncontrolled outburst that can last anywhere from five to 30 seconds to upwards of 5 minutes. And if you’ve seen – if you’ve met one of these patients or if you’ve seen the impact of PBA, you can understand that these patients are already dealing with a very significant neurologic disease or (inaudible) sustained a neurologic injury, and this uncontrolled episodes add significant burden for these patients. To give you a sense in our clinical studies, the average patient was having five to seven episodes per day. So five to seven uncontrolled emotional outbursts per day between 35 and 50 episodes per week. So it takes a significant toll on these patients.