"The data from this study reinforce our belief that NKTR-181 could potentially transform the treatment of chronic pain," said Robert Medve, MD, Chief Medical Officer at Nektar Therapeutics. "Unique to this new mu-opioid analgesic molecule is that it does not rely on a formulation to decrease its abuse liability. With a ten-fold slower entry into the brain as compared to oxycodone, NKTR-181 avoids the rush into the brain associated with euphoria. Adding to our excitement is the data that shows the peripheral analgesic and anti-hyperalgesic effects of NKTR-181 in multiple pain models. We will seek to capitalize on the properties of this unique molecule as we advance NKTR-181 into Phase 2 development this year."In a separate presentation of preclinical data at the AAPM Meeting, NKTR-181 resulted in less sedation and abuse liability as compared to oxycodone in multiple animal models across a wide range of doses. As predicted from its molecular design, NKTR-181 has a reduced rate of entry into the brain in rodents. This feature contributed to a 30-fold shift in the dose-response for abuse liability and a 10-fold shift in the dose response for sedation relative to oxycodone.
Nektar Presents Positive Proof-of-Concept Clinical Data For Its New Opioid Molecule, NKTR-181, At American Academy Of Pain Medicine's 28th Annual Meeting
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