This Day On The Street
Continue to site right-arrow
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
TheStreet Open House

Meridian Life Science® Successfully Manufactures Rhinovirus Challenge Stock

Meridian Life Science, Inc., (MLS) of Memphis, Tennessee, a wholly-owned subsidiary of Meridian Bioscience, Inc. (NASDAQ:VIVO), recently completed the manufacture of a human rhinovirus Type 16 challenge stock. MLS manufactured the rhinovirus challenge stock under contract and according to the appropriate current Good Manufacturing Procedures (cGMPs) for use in early-phase human clinical trials while simultaneously meeting the desired titer specifications under aggressive timelines.

Challenge stocks are wild type, native viruses that are fully capable of causing disease in the target population. These virus preparations are designed to be used in conjunction with clinical trials testing the efficacy of a given therapeutic. A challenge stock of infectious virus permits infection of a group of healthy volunteers where the precise viral dose, timing and progression of disease can be monitored. In turn, administration of the anti-viral therapeutic or vaccine may be tested at varying times and doses to better understand the efficacy of the drug in a controlled environment. Beyond the advantages of providing a carefully monitored test environment, the use of a challenge stock in designing an efficacy study is the increased efficiency in patient enrollment, and time to completion of the study. In clinical efficacy trials that depend on the identification of randomly infected individuals for inclusion in the study, it is common to encounter long delays and difficulties with identification of appropriate test subjects. Studies utilizing challenge stocks such as the human rhinovirus permit rapid enrollment and testing of the therapeutic resulting in significant cost savings along the road to commercialization.

Victor Van Cleave, Ph.D., Vice President of Research and Development (R&D) at Meridian Life Science, stated, “MLS is pleased to have been selected for the cGMP manufacture of a human rhinovirus Type 16 challenge stock. This project, similar to other challenge stocks and vaccines we’ve produced, was an excellent fit for MLS’ core virology and virus-based product manufacturing capabilities. The contract manufacturing process required successful technology transfer and development of a scalable production process to make this challenge stock. MLS and our scientists are proud to be a part of this drug development effort that could significantly reduce the incidence and/or severity of rhinovirus infections.”

1 of 2

Check Out Our Best Services for Investors

Action Alerts PLUS

Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
14-Days Free
Try it NOW
Only $9.95
Try it NOW
14-Days Free
Try it NOW

Check Out Our Best Services for Investors

Dividend Stock Advisor

David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks

Every recommendation goes through 3 layers of intense scrutiny—quantitative, fundamental and technical analysis—to maximize profit potential and minimize risk.

Product Features:
  • Model Portfolio
  • Intra Day Trade alerts
  • Access to Quant Ratings
Options Profits

Our options trading pros provide over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • Actionable options commentary and news
  • Real-time trading community
Try it NOW
Try it NOW
Try it NOW
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!


DOW 17,712.66 +34.43 0.19%
S&P 500 2,061.02 +4.87 0.24%
NASDAQ 4,891.2190 +27.8570 0.57%

Partners Compare Online Brokers

Free Reports

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs