This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
TheStreet Open House

Verastem IPO Looks Like Risky Bet

NEW YORK ( TheStreet -- Verastem (VSTM) hasn't tried its cancer drugs on any humans yet, but the company is hoping that won't stop investors from buying its stock.

The Cambridge, Mass.-based biopharma company is developing small molecule drugs targeted at cancer stem cells using intellectual property licensed from Harvard and MIT. It filed to go public in early November, and is seeking to raise $50 million through the sale of 4.5 million shares at $9 to $11 each. Pricing is expected this week.

There are some reasons for retail investors to sit this one out. Verastem has only been around since August of 2010, so it's very early stage, having completed preclinical mouse testing on two compounds. The company expects to file an investigational new drug application with the Food and Drug Administration in early 2013 to begin a Phase 1 clinical trial on one of the compounds -- whichever has the best outcome.

Of the proceeds from the IPO, Verastem has earmarked $25 million to $30 million to be used to complete the preclinical development of the compounds and the advancement to human testing, with the balance going to working capital and other general corporate purposes.

One of the red flags on this IPO is competition. Cancer stem cells are being targeted by other larger, more established drug companies like GlaxoSmithKline (GSK) and Pfizer (PFE), as well as a host of other smaller companies like OncoMed Pharmaceuticals, Boston Biomedical and Stemline Therapeutics.

Investors should also be warned that cancer stem cells have been at the heart of lots of controversy as to whether they are just are theory or real. Studies in 2009 questioned whether cancer stem cells even existed.

Verastem's co-founders Robert Weinberg, Eric Lander and Piyush Gupta believe they have made discoveries that unlock the transformation of a typical cancer sell to a more aggressive and drug-resistant cancer stem cell.

But investors also need to be aware that Verastem's CEO is Christoph Westphal, who sold a previous biotech company Sirtris to GlaxoSmithKline in 2008 for $720 million. The research from Sirtris has been into question following the acquisition with claims surfacing that Glaxo was bamboozled and sold worthless research.

This is a high-risk offering that gives new investors little hard proof, a tarnished executive with unproven science. In the company's own words, "Our approach to the discovery and development of product candidates that target CSCs is unproven, and we do not know whether we will be able to develop any products of commercial value."

Verastem goes on to say, "We may never succeed in these activities and, even if we do, may never generate revenues that are significant or large enough to achieve profitability. If we do achieve profitability, we may not be able to sustain or increase profitability on a quarterly or annual basis."

However, you look at it, the company is still a long ways and a lot of money away from being anything but a gamble.

-- Written by Debra Borchardt in New York.



>To contact the writer of this article, click here: Debra Borchardt.

Readers Also Like:


Disclosure: TheStreet's editorial policy prohibits staff editors, reporters and analysts from holding positions in any individual stocks.

Select the service that is right for you!

COMPARE ALL SERVICES
Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!
DOW 17,265.99 +109.14 0.64%
S&P 500 2,011.36 +9.79 0.49%
NASDAQ 4,593.4250 +31.2360 0.68%

Brokerage Partners

Rates from Bankrate.com

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs