Dr. Panagiotis Kottaridis commented, "In my experience it is unusual for any patient with AML to have subsequent CRs longer than their previous CRs. In this study, the majority of patients experienced this after treatment with CNDO-109 activated NK cells. This finding demonstrates that CNDO-109 may have a significant role in treating AML patients and supports further development of the product."
Coronado Biosciences expects to file an IND on CNDO-109 with the US FDA in the first quarter of 2012 and initiate a Phase I/II dose escalation trial in AML patients shortly thereafter.
CNDO-109 was discovered by Dr.
, Director of Cellular Therapy & Biobanking at
Royal Free Hampstead NHS Trust
and Assistant Professor and Senior Lecturer in Hematology at
University College London
CNDO-109 is a novel anti-cancer drug that primes natural killer (NK) cells without the need for cytokine (IL-2) treatment and shows significant potential for the treatment of hematological and solid tumors. CNDO-109 has produced impressive results in a Phase I clinical trial in patients with AML and demonstrated preclinical activity in multiple myeloma, breast cancer, prostate cancer and ovarian cancer.
plans to file an IND and initiate a Phase I/II dose escalation trial in AML patients in early 2012.
About Coronado Biosciences
Coronado Biosciences is engaged in the development of novel immunotherapy biologic agents. The Company's two principal pharmaceutical product candidates in clinical development are: CNDO-201, a biologic for the treatment of autoimmune diseases, such as Crohn's disease, ulcerative colitis and multiple sclerosis; and CNDO-109, a biologic that activates natural killer (NK) cells, for the treatment of acute myeloid leukemia (AML) and solid tumors. For more information, please visit
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