This Day On The Street
Continue to site right-arrow
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
TheStreet Open House

Compugen Presents Predictive Drug Target Discovery Platform At European Antibody Conference

Stocks in this article: CGEN

Speaking today at the plenary session of the 7th Annual European Antibody Congress in Geneva, Dr. Anat Cohen-Dayag, President and CEO of Compugen Ltd. (NASDAQ: CGEN), presented Compugen’s Antibody Target Discovery Platform, one of the Company's predictive discovery platforms for novel therapeutic targets. As part of her presentation covering the unique discovery capabilities of this platform, Dr. Cohen-Dayag presented experimental data demonstrating the potential of two in silico predicted proteins, CGEN-928 and CGEN-15001T, to serve as new targets for monoclonal antibody (“mAb”) based therapy.

Dr. Cohen-Dayag stated, "During the past two decades, mAbs have emerged as an important new and rapidly growing drug class, with over 20 mAbs already approved for therapeutic use in the U.S. for various clinical indications. mAb therapeutics have an exceptionally high success rate from first use in humans to regulatory approval, a rate more than double that of small molecule drugs. However, one of the main challenges in this extremely promising field is the identification of novel targets for mAb therapy. To this end, Compugen has developed several proprietary target discovery platforms through the focusing and integration of various aspects of its unique predictive discovery capabilities.”

Dr. Cohen-Dayag continued, “In addition to the two drug target candidates presented today in the conference, other promising candidates have entered our Pipeline Program and are at various stages of validation and mAb generation. We are now initiating collaborations with leading scientists from distinguished academic institutions in relevant scientific and medical fields to assist us in the further validation and development of these candidates."

In her presentation, Dr. Cohen-Dayag explained that CGEN-928 is a membrane protein which previously had no known function or potential clinical utility. However, Compugen’s Monoclonal Antibody Targets Discovery Platform predicted that this protein should have utility in the treatment of multiple myeloma, an important unmet medical need in oncology. Consistent with this prediction, CGEN-928 has now been shown by Compugen to be highly expressed in multiple myeloma samples compared with various normal tissue samples. Further studies have demonstrated broad expression of the protein in human multiple myeloma tumor cells, including late stage multiple myeloma and drug resistant and aggressive primary tumor cell lines. Thus CGEN-928’s expression profile and supporting data indicate its potential use as a target for antibody-based therapy, as well as a diagnostic and prognostic marker for multiple myeloma.

1 of 4

Check Out Our Best Services for Investors

Action Alerts PLUS

Jim Cramer and Stephanie Link reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

Jim Cramer's protégé, David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
Try it NOW
Try it NOW
Try it NOW

Check Out Our Best Services for Investors

Dividend Stock Advisor

Jim Cramer's protégé, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks

Every recommendation goes through 3 layers of intense scrutiny—quantitative, fundamental and technical analysis—to maximize profit potential and minimize risk.

Product Features:
  • Model Portfolio
  • Intra Day Trade alerts
  • Access to Quant Ratings
Options Profits

Our options trading pros provide over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • Actionable options commentary and news
  • Real-time trading community
Try it NOW
Try it NOW
Try it NOW
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!


DOW 17,387.21 -291.49 -1.65%
S&P 500 2,029.55 -27.54 -1.34%
NASDAQ 4,681.4970 -90.2660 -1.89%

Partners Compare Online Brokers

Free Reports

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs