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Curis Announces Agreement With The Leukemia & Lymphoma Society To Develop CUDC-907 For Lymphoma And Multiple Myeloma

Curis, Inc. (NASDAQ: CRIS), a drug development company seeking to develop next generation targeted small molecule drug candidates for cancer treatment, today announced that the Company has entered into an agreement under which The Leukemia & Lymphoma Society (LLS) will support Curis’s ongoing development of its oral small molecule dual Pi3K and HDAC inhibitor CUDC-907, for patients with B-cell lymphoma and multiple myeloma.

“We are delighted to collaborate with LLS to further develop CUDC-907. Our preclinical evidence suggests that its dual synergistic inhibition of PI3K and HDAC acts by disrupting cancer pathway networks that are important to the emergence and growth of B-cell lymphoma and multiple myeloma,” said Dan Passeri, Curis’s President and Chief Executive Officer. “LLS’s capital commitment to this program, along with their extensive knowledge of hematological malignancies, will be important resources as we seek to advance this promising first-in-class molecule.”

This agreement was entered into as part of LLS’s Therapy Acceleration Program (TAP), a strategic initiative to speed the development of therapies that have the potential to change the standard of care for patients with blood cancers, especially in areas of high unmet medical need.

“We look forward to working closely with Curis to accelerate the development of CUDC-907 for patients with B-cell lymphoma and multiple myeloma, who are often in critical need of new treatment options” said Richard Winneker, LLS’s senior vice president of research.

Under the agreement, LLS will fund approximately 50% of the direct costs of the development of CUDC-907, up to $4 million. Curis is currently conducting preclinical studies of CUDC-907 required to file an investigational new drug application (IND) seeking to advance the molecule into a Phase Ia dose escalation clinical trial in B-cell lymphoma and multiple myeloma. Curis expects to file the IND and start patient enrollment in the second half of 2012. If this study is successful, LLS has also agreed to support Curis’s subsequent Phase Ib or Phase IIa study in one or more specific indications as well as Curis’ ongoing investigation of biomarkers for CUDC-907 in these diseases.

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