This Day On The Street
Continue to site right-arrow
ADVERTISEMENT
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
Cramer's Action Alerts PLUS - See his portfolio and get alerts BEFORE every trade. Learn more NOW!

IBioLaunch™ Technology Successfully Applied To Modified C1 Inhibitor

NEWARK, Del., Nov. 17, 2011 /PRNewswire/ -- iBio, Inc. (NYSE AMEX: IBIO) today announced that it successfully used its proprietary iBioLaunch technology to produce full length as well as a modified form of C1 esterase inhibitor in green plants.

Plasma-derived C1 esterase inhibitor is an Orphan Drug approved by the FDA to treat or prevent the symptoms of hereditary angioedema (HAE), an inherited disorder caused by low levels of C1 esterase inhibitor that causes swelling of the face, hands, feet, throat, stomach, bowels, or sexual organs. Annual global sales of HAE treatments are expected to exceed $1 billion as new treatment options penetrate the market. Additionally, C1 esterase inhibitors are the subject of multiple research programs investigating their potential use in the treatment of other inflammatory diseases.

iBio expects the properties of its iBioLaunch-produced C1 inhibitors to be useful in the treatment of HAE and other inflammatory disorders and expects to partner the products for clinical development as part of its commercial collaboration and licensing strategy.

C1 esterase inhibitor is a protease inhibitor involved in regulation of the complement pathway.  The expression of recombinant C1 esterase inhibitor in plants using the iBioLaunch expression platform was undertaken to provide an alternative to the current method of production that involves purification from human donor plasma.  Although therapeutic proteins purified from human plasma are tested for the absence of known pathogenic viruses, recombinant production of such proteins in a plant system that does not utilize any animal products can further reduce risk.

"These results continue the successful application of iBio's technology for the production of therapeutic proteins in plants, and further confirm the flexibility and speed of this technology when applied to difficult-to-express proteins," said Dr. Terence Ryan, iBio's Senior Vice President. "The efficiency of our technology enables us to simultaneously evaluate both 'bio-similar' and 'bio-better' versions of important protein biologics."

iBio previously announced production of full-length C1 esterase inhibitor and has now produced a truncated version that retains full enzyme inhibition activity, but eliminates the need for potentially difficult and expensive post-translational modifications of the full-length protein.  Production of a form with reduced post-translational modification also results in a more homogeneous product that may provide clinical benefits and ease regulatory concerns.  

1 of 2

Check Out Our Best Services for Investors

Action Alerts PLUS

Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
14-Days Free
Try it NOW
Only $9.95
Try it NOW
14-Days Free
Try it NOW

Check Out Our Best Services for Investors

Dividend Stock Advisor

David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks

Every recommendation goes through 3 layers of intense scrutiny—quantitative, fundamental and technical analysis—to maximize profit potential and minimize risk.

Product Features:
  • Model Portfolio
  • Intra Day Trade alerts
  • Access to Quant Ratings
Options Profits

Our options trading pros provide over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • Actionable options commentary and news
  • Real-time trading community
Try it NOW
Try it NOW
Try it NOW
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!
SYM TRADE IT LAST %CHG

Markets

DOW 17,868.37 -267.35 -1.47%
S&P 500 2,076.30 -24.74 -1.18%
NASDAQ 4,937.09 -45.7190 -0.92%

Partners Compare Online Brokers

Free Reports

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs