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SENOMYX ANNOUNCES CORPORATE UPDATE AND THIRD QUARTER 2011 FINANCIAL RESULTS

Ajinomoto, Co., Inc., a leading global manufacturer of food and culinary products, has launched products that contain a Senomyx flavor ingredient in several regions, including China, North America, and most recently, an emerging country with large growth potential. Ajinomoto has continued to expand the number of product offerings, as well as their customer base, in these important markets during 2011.

Firmenich SA, a global leader in providing ingredients and flavor systems to major consumer companies, has exclusive worldwide rights to commercialize Senomyx’s S6973 sucrose enhancer for virtually all food and specified beverage categories. Firmenich has generated significant interest in S6973 with major food and beverage companies and has fulfilled orders and provided samples in support of consumer acceptance testing, further scale-up of the manufacturing process, and other pre-launch activities. The strong interest from Firmenich’s clients is based on the ability of S6973 to enable a significant reduction of sucrose while maintaining the sugar taste, combined with potential cost of goods savings.

Firmenich also has exclusive worldwide rights to market S2383, Senomyx’s extremely effective enhancer of the high-intensity sweetener sucralose, as either a stand-alone ingredient or as part of a flavor system. S2383 is applicable for use in all food and beverage product categories, including beverages, cereal, dairy products, baked goods, and confectionary products. Products incorporating S2383 are currently being marketed in North America and Firmenich has received orders to support additional product introductions in Latin America. In addition, Firmenich is working with other clients that are conducting evaluations of S2383 for a number of product lines.

Discovery & Development Program Updates:

Sweet Taste Program: The primary goal for this program is to add to the Company’s portfolio of new flavor ingredients that allow a significant reduction of sweeteners in food and beverage products while maintaining the desired sweet taste. Development activities are ongoing in support of future regulatory submissions for S9632, a new sucrose enhancer with very favorable taste and physical characteristics. Taste tests and other evaluations indicate that S9632 may be beneficial for a broad range of beverages and other product applications.

Senomyx is also working to discover and develop new flavor ingredients that amplify the sweet taste of high fructose corn syrup (HFCS), a sweetener commonly used in many beverages. The Company has identified enhancers that demonstrated the ability to reduce HFCS by up to 33% while retaining the desired sweetness profile in taste tests. Additional evaluations and taste tests with the new HFCS enhancers are ongoing. In addition, Senomyx’s activities to discover and develop natural high-potency sweeteners continue to progress. These activities include continued expansion and high-throughput screening of plant-derived samples from the Company’s natural products library, identification of the components that show significant activity in the screening assay, and scale-up of individual components of interest for taste tests. Preparations are underway for initiation of taste tests which could lead to potentially promising natural sweeteners.

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