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SENOMYX, INC. THIRD QUARTER EARNINGS CONFERENCE CALL SCHEDULED FOR OCTOBER 27, 2011

October 21, 2011-–Senomyx, Inc. (NASDAQ: SNMX) will release its third quarter 2011 financial results on Thursday, October 27, 2011 before the opening of the U.S. financial markets. The Company will also host a conference call with a live Internet broadcast that will provide a corporate update and a review of its third quarter results on the same day at 11:00 a.m. Eastern Time (8:00 a.m. Pacific Time).

To participate in the live conference call, U.S. residents should dial 888-680-0869 , and international callers should dial 617-213-4854 at least 10 minutes prior to the call start time. The participant passcode for this conference call is 18152494. Participants may pre-register for the call at anytime, including up to and after the call start time, at https://www.theconferencingservice.com/prereg/key.process?key=PN7687GJN. Pre-registrants will be issued a pin number to use when dialing into the live call, which will provide quick access to the conference.

To access the live Internet broadcast or a subsequent archived recording, please log onto the Investor Relations section of Senomyx’s website at http://investor.senomyx.com. The archived webcast will be available for 30 days following the presentation. Please connect to Senomyx’s website prior to the start of the webcast to ensure adequate time to download any software that may be necessary.

About Senomyx, Inc. ( www.senomyx.com)

Senomyx is using proprietary taste receptor technologies to discover and develop novel flavor ingredients. These include new flavors such as Savory Flavors and Cooling Flavors, as well as flavor modulators such as Bitter Blockers and enhancers of Sweet and Salt tastes. Senomyx is also engaged in a new effort to discover and develop natural high-potency sweeteners. The Company has product discovery and development collaborations with global food, beverage, and ingredient supply companies, some of which are currently marketing products that contain Senomyx’s flavor ingredients. Its corporate social responsibilities activities are described on the on the Senomyx Cares blog at http://www.senomyx-csrblog.com/. For more information, please visit www.senomyx.com.



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