Updated with additional information.
Anadys shareholder will receive $3.70 per share in cash from Roche, which represents a 256% premium over Anadys' closing price of $1.04 per share on Friday.
By acquiring Anadys, Roche hopes to develop safer, convenient and all-oral treatments for hepatitis C that do not the use of injectable interferon -- a goal shared by all of the major drug makers pursuing new hepatitis C therapies.Anadys' most advanced hepatitis C drug candidate is a pill known as setrobuvir. Results from a mid-stage study testing setrobuvir in combination with injectable interferon and ribavirin, another oral hepatitic C medicine, were announced last Thursday. On a conference call Thursday, Anadys' executives insisted that the phase II results demonstrated setrobuvir's potential to be part of a future combination therapy against hepatitis C. Yet Anadys' share price barely moved after the setrobuvir data were released last week, suggesting investors took a dimmer view of the drug's prospects. Other small, independent hepatitis C drug makers may react in sympathy Monday as investors anticipate more deal-making activity in hepatitis C. Idenix Pharmaceuticals (IDIX), Inhibitex (INHX) and Achillion Pharmaceuticals (ACHN) are all developing hepatitis C drugs that could potentially be a part of an all-oral, interferon-free regimen being pursued by larger drug companies such as Merck (MRK), Johnson & Johnson (JNJ), Abbott Labs (ABT) and Bristol-Myers Squibb (BMY). Pharmasset (VRUS) is the best-performing biotech stock this year due to the excitement over its hepatitis C drug candidates. Yet the Anadys acquisition may be perceived as a negative given Roche's existing hepatitis C partnership with Pharmasset. Investors will inevitably ask why Roche didn't acquire Pharmasset, although with a current market value of almost $6 billion, Roche may have deemed Pharmasset to be too expensive. In addition to setrobuvir, Roche's portfolio of hepatitis C drugs includes danoprevir, which it acquired from InterMune last year; RG7128 (the drug partnered with Pharmasset); and wholly owned RG7432. Roche, of course, also sells the Pegasys, the market-leading interferon. The Anadys deal may also up the pressure on existing hepatitis C powerhouse Vertex Pharmaceuticals (VRTX) to seek out new deals to develop an all-oral therapy. The commercial launch of Vertex's new, powerful hepatitis C drug Incivek has been a success but the drug must be combined with interferon and ribavrin. Vertex has a next generation hepatitis C drug, VX-222, in clinical testing but has not yet been able to find a way to make that drug work without the need for interferon. --Written by Adam Feuerstein in Boston.
>To contact the writer of this article, click here: Adam Feuerstein. >To follow the writer on Twitter, go to http://twitter.com/adamfeuerstein. >To submit a news tip, send an email to: email@example.com. Follow TheStreet on Twitter and become a fan on Facebook.
Select the service that is right for you!COMPARE ALL SERVICES
Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.
- $2.5+ million portfolio
- Large-cap and dividend focus
- Intraday trade alerts from Cramer
- Weekly roundups
Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.
- Diversified model portfolio of dividend stocks
- Alerts when market news affect the portfolio
- Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
24/7 market commentary from Jim Cramer and 20+ veteran Wall Street gurus. Get access to the latest trading ideas on stocks, options, and ETFs as well as a real-time forum to see the pros exchanging their investment ideas.
- Jim Cramer + 20 Wall Street pros
- Intraday commentary & news
- Real-time trading forum
- Actionable trade ideas
All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.
- Real Money + Doug Kass + 15 more Wall Street Pros
- Intraday commentary & news
- Ultra-actionable trading ideas
Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.
- 100+ monthly options trading ideas
- Actionable options commentary & news
- Real-time trading community
- Options TV