This Day On The Street
Continue to site right-arrow
ADVERTISEMENT
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
TheStreet Open House

Curis Announces Dosing Of First Patient In Phase I CUDC-101 Head And Neck Cancer Combination Trial

Curis, Inc. (NASDAQ: CRIS), a drug development company seeking to develop next generation targeted small molecule drug candidates for cancer treatment, today announced that the first patient has been treated in a Phase I combination trial of CUDC-101. The Phase I trial is the Company’s first CUDC-101 combination study and is designed to test CUDC-101 when administered concurrently with radiation and cisplatin in human papillomavirus negative (HPV-) locally advanced head and neck cancer patients. CUDC-101 is a first-in-class small molecule drug candidate that has been designed as an inhibitor of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (Her2) and histone deacetylase (HDAC).

The first patient was treated at the University of Colorado Cancer Center under the care of Antonio Jimeno, M.D., Ph.D. “We are excited to participate in this trial, which primarily aims to establish the optimal combination dose of CUDC-101 when combined with current standard of care radiation and cisplatin as well as to build on Curis’ previous clinical observations in which signs of biological activity were observed with single-agent CUDC-101 in advanced head and neck cancer patients," commented Dr. Jimeno. "We believe that CUDC-101 is a potentially promising drug candidate in the head and neck cancer setting and we look forward to exploring the potential of CUDC-101 in combination with radiation and cisplatin in this study.”

Dan Passeri, Curis’ President and Chief Executive Officer, added, “This trial is significant for Curis as it provides the first combination study of CUDC-101 with other agents in a clinical setting, and it also advances the development of this molecule in a front-line indication that we believe is ideally-suited for CUDC-101. It has been shown that most head and neck cancers overexpress EGFR and that a portion of these tumors also overexpress Her2, both molecular targets of CUDC-101. Furthermore, CUDC-101 has demonstrated clinical activity in head and neck cancer in Curis’ previous dose escalation and expansion studies. In addition, preclinical data suggests that HDAC inhibition, the third target of CUDC-101, can enhance the effects of both radiation and cisplatin therapy. A majority of head and neck cancers are HPV-, and patients with these tumors experience a poorer clinical outcome than patients whose tumors are HPV positive. We are pleased to have begun this important trial and we look forward to providing updates on our progress in the future.”

1 of 5

Check Out Our Best Services for Investors

Action Alerts PLUS

Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
14-Days Free
Try it NOW
Only $9.95
Try it NOW
14-Days Free
Try it NOW

Check Out Our Best Services for Investors

Dividend Stock Advisor

David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks

Every recommendation goes through 3 layers of intense scrutiny—quantitative, fundamental and technical analysis—to maximize profit potential and minimize risk.

Product Features:
  • Model Portfolio
  • Intra Day Trade alerts
  • Access to Quant Ratings
Options Profits

Our options trading pros provide over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • Actionable options commentary and news
  • Real-time trading community
Try it NOW
Try it NOW
Try it NOW
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!
SYM TRADE IT LAST %CHG

Markets

DOW 17,678.23 -40.31 -0.23%
S&P 500 2,056.15 -4.90 -0.24%
NASDAQ 4,863.3620 -13.1570 -0.27%

Partners Compare Online Brokers

Free Reports

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs