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SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2011 FINANCIAL RESULTS

Ajinomoto, Co., Inc., a leading global manufacturer of food and culinary products, has been introducing products that contain a Senomyx flavor ingredient in several regions, including both China and North America. Penetration of these markets continues to increase. Most recently, Ajinomoto achieved further geographic expansion into another emerging market with large growth potential.

Firmenich SA, a global leader in providing ingredients and flavor systems to major consumer companies, has exclusive worldwide rights to commercialize Senomyx’s S6973 sucrose enhancer for virtually all food and specified beverage categories. Firmenich has met its goal of receiving initial orders for S6973 beginning in the second quarter of 2011. Evaluations of S6973 in products from a number of categories have been very favorable and additional orders are expected from several clients during the year.

Firmenich also has exclusive worldwide rights to market S2383, Senomyx’s extremely effective enhancer of the high-intensity sweetener sucralose, as either a stand-alone ingredient or as part of a flavor system. S2383 is applicable for use in all food and beverage product categories, including beverages, cereal, dairy products, baked goods, and confectionery products. Products incorporating S2383 are currently being marketed in North America and Firmenich is working with additional clients that are evaluating S2383 for a number of product lines.

Discovery & Development Program Updates:

Sweet Taste Program: The primary goal for this program is to identify flavor ingredients that allow a significant reduction of sweeteners in food and beverage products while maintaining the desired sweet taste. Senomyx had success in this program with the discovery, development, and GRAS (Generally Recognized As Safe) regulatory approvals of S2383 and S6973. Senomyx has initiated development activities in support of future regulatory submissions for S9632, a new sucrose enhancer with very favorable taste and physical characteristics. Initial taste tests and other evaluations have indicated that S9632 may be beneficial for a broad range of beverages and other product applications.

Senomyx also has an ongoing effort to discover and develop new flavor ingredients that amplify the sweet taste of fructose, a key component of high fructose corn syrup. The Company has identified enhancers that demonstrated activity in its proprietary fructose screening assays and enhancing activity in taste tests utilizing high fructose corn syrup, a commonly used sweetener in many beverages. Optimization of these enhancers, further screening, and additional taste tests are ongoing. In addition, Senomyx’s activities to discover and develop natural high-potency sweeteners continue to progress. Current activities include continued expansion and high-throughput screening of plant-derived samples from our natural products library, identification of the components that show significant activity in the assay, and scale-up of these samples for in-house taste tests.

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