Cabozantinib is garnering a lot of attention because of previously released data from a mid-stage study demonstrating the drug's ability to both shrink and stabilize tumors but also fully or partly eliminate cancer that had spread to bone in patients with prostate, breast and skin cancer. Cabozantinib has also shown activity against ovarian cancer.
Cancer that metastasizes, or spreads, to bones is a serious complication leading to fractures, increased pain and eventual death. While many cancer drugs can shrink or eliminate tumors in soft tissue, few if any have demonstrated an ability to clear up bone metastases.
Of 65 prostate cancer patients evaluated with bone scans, 56 patients, or 86%, had partial or full resolution of bone lesions. Tumors shrank significantly in 5% of patients, while 71% of patients overall exhibited tumor shrinkage or tumor stabilization.
At the ASCO meeting, researchers will update these cabozantinib data with additional prostate cancer patients and longer follow up, including data aimed at measuring whether the drug can delay the re-growth of tumors and possibly prolong survival. Other researchers will present new data on cabozantinib's activity in heavily pre-treated ovarian cancer.Additional new data disclosed Wednesday in the ASCO research abstracts include:
Women with ovarian cancer responding to initial treatment with chemotherapy were then randomized to receive further maintenance treatment with AstraZeneca's olaparib or a placebo. Tumor re-growth was delayed by 8.4 months in the women treated with olaparib compared to 4.8 months for women given a placebo.
Abraxane's overall response rate was 33% compared to 25% for paclitaxel -- a statistically significant benefit that was maintained when patients responses were analyzed by countries of origin -- Russia/Ukraine, Asia/Pacific and North American/Australia. Despite the improved response rate, Abraxane did not prolong the time before tumors started growing again compared to paclitaxel. A survival analysis from the study will be presented at the ASCO meeting.
Celgene will seek FDA approval later this year to expand Abraxane's label to include treatment for lung cancer. The drug is already approved to treat breast cancer.
Nektar is developing NKTR-102 in ovarian and breast cancer and is expected to outline details of phase III studies at ASCO.
>To contact the writer of this article, click here: Adam Feuerstein. >To follow the writer on Twitter, go to http://twitter.com/adamfeuerstein. >To submit a news tip, send an email to: firstname.lastname@example.org.
Select the service that is right for you!COMPARE ALL SERVICES
Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.
- $2.5+ million portfolio
- Large-cap and dividend focus
- Intraday trade alerts from Cramer
- Weekly roundups
Access the tool that DOMINATES the Russell 2000 and the S&P 500.
- Buy, hold, or sell recommendations for over 4,300 stocks
- Unlimited research reports on your favorite stocks
- A custom stock screener
- Upgrade/downgrade alerts
Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.
- Diversified model portfolio of dividend stocks
- Alerts when market news affect the portfolio
- Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.
- Real Money + Doug Kass Plus 15 more Wall Street Pros
- Intraday commentary & news
- Ultra-actionable trading ideas
Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.
- 100+ monthly options trading ideas
- Actionable options commentary & news
- Real-time trading community
- Options TV