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SENOMYX ANNOUNCES CORPORATE UPDATE AND FIRST QUARTER 2011 FINANCIAL RESULTS

April 29, 2011-–Senomyx, Inc. (NASDAQ: SNMX), a company focused on using proprietary taste receptor-based technologies to discover novel flavor ingredients for the food, beverage, and ingredient supply industries, today provided a corporate update and reported financial results for the first quarter ended March 31, 2011. Revenues were $8.7 million for the three months ended March 31, 2011, a 13% increase compared to 2010. Net loss was $1.3 million for the three months ended March 31, 2011, a 29% improvement compared to 2010.

“We are off to a strong start in 2011,” stated Kent Snyder, Chief Executive Officer of the Company. “Our partners continue to make good progress with their commercialization activities, and we continue to advance our Discovery & Development programs. In addition, Senomyx has maintained a strong balance sheet with approximately $66 million in cash as of March 31 st.

“We are especially encouraged by Firmenich’s activities with S6973, which allows sucrose to be reduced in products by up to 50% while maintaining the taste of natural sugar desired by consumers,” Snyder said. “Firmenich has produced commercial quantities of S6973 and they expect to record their first commercial sale to a major-brand customer during the second quarter. These activities are concurrent with Firmenich’s sales of S2383, which can be used in numerous products to enable up to a 75% reduction in the concentration of sucralose, and in some applications also improves taste.

“As we announced earlier this week, Senomyx was very pleased to have been granted a U.S. patent that includes composition claims covering S2383 and its analogs. S2383 has unique attributes regarding its function and taste characteristics that make it a valuable asset for the Company. The new patent was issued on April 19, 2011 and has a term through June 8, 2027. In addition to providing IP protection and exclusivity in the marketplace for a long period of time, the patent is an important validation of our research capabilities,” Snyder noted.

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