- As with all metformin products, lactic acidosis due to metformin accumulation during treatment with GLUMETZA is a rare but potentially fatal occurrence.
- May also occur in association with a number of pathophysiologic conditions.
- The risk of lactic acidosis increases with the degree of renal dysfunction and the patient’s age, especially patients ≥80 years of age, and in those patients with congestive heart failure requiring pharmacologic management.
- The risk of lactic acidosis while on GLUMETZA therapy may be significantly decreased by initial and regular monitoring of renal and liver function; using the minimum effective dose; withholding in the presence of any condition associated with hypoxemia, dehydration, or sepsis; avoidance in patients with hepatic disease; cautioning patients against excessive alcohol intake; temporarily discontinuing prior to any intravascular radiocontrast study or surgical procedure.
- Lactic acidosis is a medical emergency requiring immediate discontinuation of GLUMETZA.
- General supportive measures and prompt hemodialysis are recommended to correct the acidosis and remove the accumulated metformin.
Santarus And Depomed Announce Availability Of GLUMETZA 500 Mg Tablets
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