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TheStreet Open House

Health Discovery Corporation 2010 Shareholder Letter

Dear Fellow Shareholders:

Since I wrote you this past November 2009, the global economy continues to be deeply shaken, the financial markets are in turmoil, significant unemployment continues and the Gulf has absorbed a massive oil spill. Major health care legislation became U.S. law and will formally incorporate tens of millions of new patients into the health care insurance market. This past year has been historic for these and many other reasons.

For Health Discovery Corporation (the “Company”) (OTCBB:HDVY), this has been a time of significant achievement and real progress. We believe the Company overall has never been in a better position for achieving success now and in the future. We continue to be a company on the move and I would like to provide you with a summary of our recent activities.

People

We have added a number of new people to assist in the growth our business. To our management team we have added Tom Gallagher, a Wall Street securities lawyer and former Vice President of Goldman, Sachs & Co. (NYSE: GS), as Executive Vice President; John Norris, a former Deputy Commissioner of the FDA has joined the Company as COO; and Maher Albitar, M.D., a world-class scientist, inventor and author of more than 250 peer-reviewed medical publications has joined our team as Chief Medical Officer.

Dr. Albitar is a globally respected cancer researcher with a combination of both academic and commercial experience having held high-level appointments at Quest Diagnostics, Incorporated (NYSE: DGX), the largest commercial clinical laboratory in the world and MD Anderson Cancer Center, one of the leading cancer centers in the U.S.

This past spring we added Paul Graham of Graham Capital Partners to our Board of Directors and have benefited from his 25 years in national and international investment banking, mergers and acquisitions, and finance.

Our Science Advisory Board expanded by the addition of Nitesh Chawla, Ph.D., a professor in the Department of Computer Science and Engineering and co-director of the Interdisciplinary Center for Network Science and Applications at the University of Notre Dame, South Bend, Indiana. Dr. Chawla is an expert in machine learning.

We are delighted that these professionals have joined the talented team already assembled at Health Discovery Corporation.

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