Symyx Technologies, Inc. Mails Letter To Stockholders

Symyx Technologies, Inc. (NASDAQ: SMMX) today announced that it is mailing the following letter to stockholders in connection with its June 30, 2010 Special Meeting of Stockholders:

June 21, 2010

Dear Symyx Stockholder:

At Symyx Technologies, Inc.’s upcoming Special Meeting of Stockholders scheduled for June 30, 2010, you will be asked to vote on the proposed merger between Symyx and Accelrys, Inc. As announced on April 5, 2010, the transaction was approved by both companies’ boards of directors and is structured as a tax-free, all-stock merger of equals. Under the terms of the agreement, Symyx stockholders will receive 0.7802 of a share of Accelrys common stock for each share of Symyx they own. Following the completion of the merger, Accelrys and Symyx stockholders will each own approximately 50 percent of the combined company.

The Symyx board has concluded that the proposed merger with Accelrys is in the best interests of Symyx and all of its stockholders. We urge you to vote “FOR” the proposed merger on the enclosed proxy card today.

Symyx and Accelrys are each leaders in the scientific software and services market with scientific expertise in chemistry, biology and materials science. Our two companies possess a deep understanding of the challenges facing scientific R&D organizations. By bringing together our two companies and our unique and powerful resources, we will be better positioned to meet the changing and increasingly complex needs of customers by delivering more agile, complete and open scientific R&D environments. Combined, we will be better able to deliver a broader range of solutions and services and achieve better outcomes for our global customers. Additionally, the combined company will have an impressive customer base with more than 1,350 customers, including 29 of the top 30 biopharmaceutical companies, all five top chemical companies, all five top aerospace companies, three of the five top consumer packaged goods companies, a number of top US Federal Government Agencies, as well as many top academic institutions.