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Osmolarity, Dry Eye Disease And TearLab, Front And Center At ARVO 2010

SAN DIEGO, May 6, 2010 (GLOBE NEWSWIRE) -- OccuLogix, Inc., dba TearLab Corporation ("TearLab") (Nasdaq:TEAR) (TSX:TLB) today announced today that a variety of paper and poster presentations given at the 2010 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO) highlighted tear film osmolarity as the preferred tool in the evaluation of patients suffering from Dry Eye Disease ("DED") and further validated TearLab's™ unique ability to accurately measure subtle changes in the condition of the ocular surface.

ARVO was founded in 1928 and is the largest research gathering for ophthalmologists and vision scientists in the world. Its membership is comprised of more than 12,500 individuals from 70 countries. The membership is multidisciplinary and consists of both clinical and basic researchers. ARVO is based in Rockville, Maryland.  This year's ARVO annual meeting was held in Fort Lauderdale, Florida.

One poster presentation, entitled "Longitudinal Variability of Tear Film Osmolarity in Normal and Dry Eye Patients" and presented by David Eldridge, OD, FAAO, described a study that was designed to evaluate the variability of right ("OD") and left ("OS") eye tear film osmolarity relative to tear film instability in the diagnosis of DED. At each subject visit, 50 nanoliters of tear fluid was simultaneously collected and analyzed (both OD and OS) by the TearLab™ Osmolarity System in triplicate. The average of normal subjects was 301.8±10.5 mOsms/L {range 290.2-307.7} while the average of hyperosmolar subjects was 315.6±18.6 mOsms/L {range 308.1-329.4} indicating early stage mild disease. Variability was strongly positively correlated with average osmolarity (r2 = 0.52), suggesting that tear film instability increased in DED.  When the highest of either the OD or OS osmolarity result of an individual was considered, 86% of the early stage, mild dry eye subjects, the most difficult stage to diagnose, were correctly identified with the first set of measurements. Dr. Eldridge's presentation concluded that variability in osmolarity is a hallmark of DED, reflecting the inability of the patient to maintain tear film homeostasis. Therefore, he recommended that physicians test both eyes to diagnose DED and use the higher of two values for proper clinical assessment.

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