Dendreon's (DNDN) prostate cancer vaccine Provenge appears to cut the risk of death compared with a placebo, but the interim results were not robust enough to stop the ongoing clinical trial early.
Investors focused on the promising Provenge survival data Monday morning and looked past the disappointment that Dendreon would be unable to seek early approval for the experimental cancer vaccine.
Shares of Dendreon were up 65% to $8.58 in recent trading.
Monday's results came from an interim analysis of a phase III study of Provenge in patients with advanced prostate cancer. An independent data monitoring committee informed Dendreon that the study should continue to a final analysis planned for the middle of 2009.At the same time, however, the data crunchers reported that prostate cancer patients treated with Provenge had a 20% reduction in the risk of death compared with patients treated with a placebo. If Provenge can reduce the risk of death by 22% compared with placebo at the final analysis, the study will be successful, Dendreon said Monday. In previous studies, Provenge has been shown to have a delayed positive impact on survival. And so far, patients in the ongoing Provenge study, dubbed IMPACT, are acting very much like patients in the old Provenge studies. These two factors prompted Dendreon CEO Mitch Gold to call today's results "encouraging." "We're looking forward to seeing the final results next year," he said. Provenge's ability to reduce the risk of death by 20% looks impressive at the interim analysis, but the result was neither statistically significant nor strong enough to stop the study early. Achieving a 22% reduction in the risk for death at the final analysis -- and making that result statistically significant -- could still be a struggle for Dendreon.
Select the service that is right for you!COMPARE ALL SERVICES
Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.
- $2.5+ million portfolio
- Large-cap and dividend focus
- Intraday trade alerts from Cramer
- Weekly roundups
Access the tool that DOMINATES the Russell 2000 and the S&P 500.
- Buy, hold, or sell recommendations for over 4,300 stocks
- Unlimited research reports on your favorite stocks
- A custom stock screener
- Upgrade/downgrade alerts
Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.
- Diversified model portfolio of dividend stocks
- Alerts when market news affect the portfolio
- Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.
- Real Money + Doug Kass Plus 15 more Wall Street Pros
- Intraday commentary & news
- Ultra-actionable trading ideas
Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.
- 100+ monthly options trading ideas
- Actionable options commentary & news
- Real-time trading community
- Options TV