Friday's Winners & Losers: Cleveland BioLabs

Small chipmaker Micrel Semiconductor(MCRL Quote) sunk 19.7% after it reduced its fourth- quarter guidance. The company said it now projects revenue to be approximately $64 million, which is lower than its Oct. 25 forecast of $66.5 million to $67.8 million.

The shortfall is attributed to lower-than-expected orders from customers in China and Korea. Earnings are now forecast in the range of 10 cents to 11 cents, compared with previous guidance of 13 cents. Shares of Micrel were off $1.54 to $6.28.

Apple(AAPL Quote) has retreated significantly from the $200-mark on Dec. 26 and was off $14.88, or 7.6%, to $180.05 Friday.

The stock was down despite a research note from Goldman Sachs that said Apple enjoyed good holiday sales and is likely to report strong earnings in the first quarter. Goldman also raised its six-month price target for Apple stock to $220 from $205.

Regions Financial (RF Quote) plunged 10.7% to $20.80, after the Alabama bank said it will set aside some $360 million in the fourth quarter to cover bad credit, compared with $270 million last quarter. The provision, the girth of which is largely due to Regions' souring portfolio of homebuilding loans, comes to 1.45% of total loans vs. 1.19% last quarter.

Among the few financial winners on Friday was Michigan insurer North Pointe (NPTE Quote), shares of which rocketed 45.9% after Australia-based QBE Insurance agreed to buy it for $16 a share in cash, or about $146 million. The deal should close in the first half. North Pointe shares soared $4.86 to $15.44.