Wedneday's Winners & Losers: Take-Two Takes Off

Video-games publisher Take-Two(TTWO Quote) added 4% after the company shrank its fourth-quarter losses.

But its first-quarter guidance came in lower than Wall Street expectations. Take-Two hopes the release of its much awaited game, Grand Theft Auto IV in the second quarter fiscal 2008 will help beat analysts' expectations for the fiscal year. Take-Two was up $1.18 to $19.21.

Chipmaker AMD(AMD Quote) came off its 52-week low and gained 3.9%. The stock had been crushed in the last few days as investors were bearish on the company's growth prospects.

AMD had an analysts meet last week at which it said it has delayed the release of a key product code-named Barcelona, though it hopes to hit profitability in the second half of 2008. Abiomed(ABMD Quote) said Wednesday that the Food and Drug Administration approved its iPulse Circulatory Support System, which supports devices designed to treat patients who suffer from acute heart failure.

The company said it's the first approved device to support ventricular assist devices and intraaortic balloons in the catheterization lab and surgery suite.

Shares edged up 1.9%.

On the falling end, Neurocrine(NBIX Quote), which recently tanked after the FDA didn't approve its sleep drug indiplon and later announced that it would cut staff by 130 people, was still on the decline Wednesday.