Friday's Small-Cap Winners & Losers

Updated from 2:52 p.m. EDT

The small-cap sector was sluggish again Friday, under pressure from plummeting names like data-storage-systems maker Isilon Systems (ISLN Quote).

Shares lost more than a third of their value after the Seattle-based company pegged third-quarter sales at $25 million to $27.5 million, or at least $3.9 million below the mean analyst forecast, according to Thomson Financial. Its second-quarter non-GAAP loss was in line, but shares still lost $5.37 to $9.54.

Anadys Pharmaceuticals (ANDS Quote) shares were also pummeled on news the San Diego company, along with partner Novartis(NVS Quote), halted early-phase development of their hepatitis C treatment ANA975. The companies determined that "chronic daily dosing ... is inappropriate for further clinical development" in light of animal-toxicology results. Anadys shares plunged 28.9% to $2.34.

Elsewhere, New York theme-park operator Six Flags (SIX Quote) tumbled 16.8% to $3.90 after widening its second-quarter continuing-operations loss by 3 cents year over year to 50 cents a share. Revenue, at $344.8 million, was also below the sole analyst's estimate.

Volcom (VLCM Quote) slid as well after the Costa Mesa, Calif., apparel maker predicted it would make 53 cents to 55 cents a share in the third quarter -- at least 7 cents under the Street's consensus. Shares gave up $6.30, or 14.2%, to $38.04.

On the flip side, lululemon athletica (LULUV:Nasdaq) soared 55.6% after its initial public offering. The athletic-apparel company priced 18.2 million shares at $18 apiece, mostly from selling stockholders. Underwriters have an option for 2.73 million more to cover any overalloments. Shares closed up $10 to $28.