This Day On The Street
Continue to site right-arrow
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
Stocks Under $10 with 50-100% upside potential - 14 days FREE!

FDA Warns About Naproxen

Updated from 8:26 a.m. EST

There's more pain for drugmakers and new worries for drug users.

The Food and Drug Administration is now warning about heart risks related to the use of naproxen, a long-time popular pain killer sold over the counter, as well as a prescription-strength medication sold under various names.

The latest shock to the industry came Monday night when federal regulators disclosed that the National Institutes of Health last Friday halted a drug study testing whether certain anti-inflammatory drugs could reduce the risk of patients contracting Alzheimer's disease. The drugs were being tested in people 70 years of age or older who were considered to be at increased risk because of family history, but did not have symptoms of the disease.

The study compared Naproxen vs. Celebrex, which is made by Pfizer (PFE). The best-known over-the-counter version of the drug Naproxen is Aleve.

The Alzheimer's disease test was halted partly because another clinical study involving Celebrex showed that the Pfizer drug increased the risk of cardiovascular problems among patients who took high doses, a development that Pfizer disclosed last Friday and which triggered a selloff in the company's share price. The test, sponsored by the National Cancer Institute, was determining if Celebrex could prevent certain colon polyps that are a precursor to colon cancer.

But this Alzheimer's disease test, called ADAPT, was also halted because it "indicated an apparent increase in cardiovascular and cerebrovascular events" among naproxen patients vs. patients receiving a placebo, the NIH said Monday night.

The test was stopped "as a precautionary measure to ensure the safety of the study's participants," said NIH Director Dr. Elias A. Zerhouni. "The investigators made their decision based on the risk/benefit analysis specific to this trial." The ADAPT trial began in 2001 and was conducted at six U.S. sites. Approximately 2400 volunteer participants were randomly assigned to receive naproxen, Celebrex or a placebo for a time up to three years.

1 of 3

Select the service that is right for you!

Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!


DOW 17,778.15 +421.28 2.43%
S&P 500 2,061.23 +48.34 2.40%
NASDAQ 4,748.3960 +104.0840 2.24%

Brokerage Partners

Rates from

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs