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Page 4 of 591

Celladon Heart-Failure Study Looms Large as Next Big Test for Gene Therapy

By Adam Feuerstein

In April, Celladon is expecting results from a mid-stage study of a gene therapy aiming to improve the pumping ability of the heart in patients with advanced heart failure.

10:06AM 03/25/15

PTC Therapeutics CEO Liquidates Stock Ownership in His Own Company

By Adam Feuerstein

Biotech CEOs are supposed to be cheerleaders for their stock, so it's noteworthy when a CEO's pocketbook indicates otherwise.

10:39AM 03/24/15

High Alert for Signs of Biotech Collapse Makes for Nervous Investors

By Adam Feuerstein

Biotech stocks may or may not be in a bubble, but investors are definitely worried about sky-high valuations.

08:56AM 03/24/15

Vertex Cystic-Fibrosis Drug Smacked by Burden of High Expectations

By Adam Feuerstein

Vertex disclosed some new phase IIb study results that raise concerns VX-661 may not be as potent as previously hoped.

09:07AM 03/23/15

Biogen, Alzheimer's and the Biotech Mania (Is It a Bubble?)

By Adam Feuerstein

Biogen shares are up on strong Alzheimer's drug data, but is the biotech bull market making investors forget about risk?

12:29PM 03/20/15

Biotech Stock Mailbag: Breaking the Feuerstein-Ratain Rule; Medical Conferences; Celgene

By Adam Feuerstein

Biotech columnist Adam Feuerstein answers readers' questions about health care companies.

07:18AM 03/20/15

Biogen's Alzheimer's Drug Exceeds (or Meets) Expectations, Depending on Your View

By Adam Feuerstein

Biogen Idec's drug BIIB037 slowed cognitive decline and reduced brain plaques in Alzheimer's patients.

06:40AM 03/20/15

Amicus Accelerates Approval Filing Plans for Rare Disease Drug

By Adam Feuerstein

Amicus will seek accelerated approval in the U.S. for its Fabry disease therapy in the second half of the year -- sooner than many investors expected.

07:41AM 03/19/15

Celgene's Crohn's Disease Drug Candidate Highlighted in NEJM

By Adam Feuerstein

Celgene will be starting phase III studies of mongersen in Crohn's disease -- designed to lead to the drug's approval -- by the middle of the year.

05:00PM 03/18/15

MannKind's Financial Health Complicated by Looming $100M Debt Payment

By Adam Feuerstein

MannKind is facing a cash shortfall unless it can settle with debt holders by August.

09:17AM 03/18/15

Page 4 of 591

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